Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.59 |
| ▸ | RAB9A | P51151 | 8/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 3/20 | 0.56 |
| ▸ | MAOB | P27338 | 3/20 | 0.56 |
| ▸ | PLAU | P00749 | 1/20 | 0.53 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.50 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27697702 | 0.83 | RAB9A (0.61) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL20524671 | 0.83 | NOTUM (0.56) | NPC1RAB9ASMN1; SMN2MAPTNOTUM | |
| SCHEMBL30323171 | 0.83 | NOTUM (0.56) | NPC1RAB9ASMN1; SMN2MAPTNOTUM | |
| SCHEMBL30300424 | 0.83 | NOTUM (0.62) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL4652262 | 0.82 | BRD4 (0.54) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL19538829 | 0.81 | MAPT (0.61) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL6194177 | 0.81 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL14022344 | 0.79 | KMT2A (0.57) | RAB9ASMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL15011337 | 0.75 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL7101847 | 0.73 | PABPC1 (0.79) | NPC1RAB9ASMN1; SMN2MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12492193-B2 | Pyrazole derivatives for the treatment of cystic fibrosis | FONDAZIONE INSTITUTO ITALIANO DI TECNOLOGIA (IT) | 2025-12-09 | — | — | US | claimed |
| CN-101052634-B | Anthranilamide pyridinureas as vegf receptor kinase inhibitors | BAYER SCHERING PHARMA AG | 2011-05-18 | — | — | CN | disclosed |
| CN-101056871-A | Novel anthranilamide pyridinureas as vegf receptor kinase inhibitors | BAYER SCHERING PHARMA AG (DE) | 2007-10-17 | — | — | CN | disclosed |
| CN-101052634-A | Anthranilamide pyridinureas as vegf receptor kinase inhibitors | BAYER SCHERING PHARMA AG (DE) | 2007-10-10 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12492193-B2 | Pyrazole derivatives for the treatment of cystic fibrosis | CFTR, ABCC5, ABCC1 | NPC1 137/4885RAB9A 1996/4885SMN1; SMN2 4800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.