Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 2/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27678877 | 0.84 | APEX1 (0.53) | APEX1PTGDR2KDM4E | |
| SCHEMBL27678874 | 0.81 | APEX1 (0.54) | APEX1PTGDR2KDM4E | |
| SCHEMBL4716045 | 0.76 | GLA (0.57) | APEX1PTGDR2KDM4E | |
| SCHEMBL28901984 | 0.71 | PARP1 (0.52) | POLB | |
| SCHEMBL29412023 | 0.71 | PARP1 (0.52) | POLB | |
| SCHEMBL1890982 | 0.70 | APEX1 (0.49) | APEX1PTGDR2KDM4E | |
| SCHEMBL4715837 | 0.69 | GLA (0.48) | APEX1PTGDR2KDM4EPOLBALDH1A1 | |
| SCHEMBL4714008 | 0.69 | GLA (0.51) | APEX1PTGDR2KDM4EALDH1A1GAA | |
| SCHEMBL5121022 | 0.69 | PTGDR2 (0.46) | APEX1PTGDR2KMT2AKDM4EHSD17B10 | |
| SCHEMBL4292873 | 0.67 | KDM4E (0.65) | APEX1PTGDR2MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101052397-A | 2-sulfanyl-benzoimidazol-1-yl-acetic acid derivatives | ACTELION PHARMACEUTICALS LTD (CH) | 2007-10-10 | — | — | CN | disclosed |