Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 3/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27678877 | 0.95 | APEX1 (0.53) | APEX1AGTR1AGTR2PTGDR2KDM4E | |
| SCHEMBL27697873 | 0.81 | APEX1 (0.51) | APEX1PTGDR2KDM4E | |
| SCHEMBL1890982 | 0.75 | APEX1 (0.49) | APEX1AGTR1AGTR2PTGDR2KDM4E | |
| SCHEMBL9422759 | 0.75 | APEX1 (0.84) | APEX1AGTR1AGTR2PTGDR2KDM4E | |
| SCHEMBL8931821 | 0.74 | APEX1 (0.47) | APEX1AGTR1AGTR2PTGDR2KDM4E | |
| SCHEMBL28238965 | 0.69 | HPGD (0.48) | KDM4ETLR7 | |
| SCHEMBL4558471 | 0.68 | ALDH1A1 (0.49) | APEX1PTGDR2KDM4E | |
| SCHEMBL9531115 | 0.68 | APEX1 (0.65) | APEX1AGTR1AGTR2PTGDR2KDM4E | |
| SCHEMBL3825019 | 0.67 | TLR7 (0.42) | APEX1PPARGTLR7 | |
| SCHEMBL668252 | 0.67 | LMNA (0.66) | APEX1AGTR1AGTR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101052397-A | 2-sulfanyl-benzoimidazol-1-yl-acetic acid derivatives | ACTELION PHARMACEUTICALS LTD (CH) | 2007-10-10 | — | — | CN | disclosed |