Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SGMS2 | Q8NHU3 | 7/20 | 0.34 |
| ▸ | SGMS1 | Q86VZ5 | 4/20 | 0.34 |
| ▸ | NMT2 | O60551 | 3/20 | 0.33 |
| ▸ | NMT1 | P30419 | 3/20 | 0.33 |
| ▸ | MLYCD | O95822 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | UGCG | Q16739 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2768890 | 0.82 | ALDH1A1 (0.34) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2767898 | 0.81 | NPC1 (0.37) | NPC1RAB9ASMN1; SMN2SGMS2SGMS1 | |
| SCHEMBL2767552 | 0.79 | KCNA5 (0.36) | SGMS2SGMS1KCNA5HCRTR2UGCG | |
| SCHEMBL3560647 | 0.78 | KCNA5 (0.36) | SMN1; SMN2SGMS2SGMS1KCNA5HCRTR2 | |
| SCHEMBL2786528 | 0.78 | HIF1A (0.36) | SGMS2SGMS1KCNA5UGCG | |
| Cyclohexane SCHEMBL2442882 | 0.78 | KCNA5 (0.39) | SMN1; SMN2SGMS2SGMS1KCNA5UGCG | |
| Cyclopropane SCHEMBL2441865 | 0.78 | KCNA5 (0.39) | SMN1; SMN2SGMS2SGMS1KCNA5UGCG | |
| SCHEMBL2771751 | 0.77 | TP53 (0.39) | NPC1RAB9ASMN1; SMN2SGMS2SGMS1 | |
| SCHEMBL2439003 | 0.75 | KDM4E (0.42) | SGMS2SGMS1KCNA5UGCG | |
| SCHEMBL2442656 | 0.74 | KCNA5 (0.40) | SMN1; SMN2SGMS2SGMS1KCNA5UGCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |
| US-20080176915-A1 | Substituted Benzo[d]isoxazol-3-yl Amine Compounds as Analgesics | GRUENENTHAL GMBH (DE) | 2008-07-24 | — | — | US | claimed |
| US-7696238-B2 | Substituted benzo[d]isoxazol-3-yl amine compounds as analgesics | GRUENENTHAL GMBH (DE) | 2010-04-13 | — | — | US | disclosed |
| US-20080176915-A1 | Substituted Benzo[d]isoxazol-3-yl Amine Compounds as Analgesics | GRUENENTHAL GMBH (DE) | 2008-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176915-A1 | Substituted Benzo[d]isoxazol-3-yl Amine Compounds as Analgesics | KCNQ1, KCNQ2, KCNQ3 | NPC1 2230/4885RAB9A 3127/4885SMN1; SMN2 1349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.