SCHEMBL27698463

SCHEMBL27698463

O=C(Oc1ccc(F)cc1)c1cccc2ncoc12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.43
MAPT P10636 5/20 0.43
KDM4E B2RXH2 4/20 0.43
KMT2A Q03164 8/20 0.42
ATM Q13315 1/20 0.42
HPGD P15428 3/20 0.39
CYP1A2 P05177 1/20 0.39
HSD17B10 Q99714 3/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
ALOX15 P16050 2/20 0.38
USP2 O75604 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
TSHR P16473 1/20 0.37
MEN1 O00255 3/20 0.37
TDP1 Q9NUW8 1/20 0.37
NPSR1 Q6W5P4 1/20 0.36
MTNR1A P48039 2/20 0.36
MTNR1B P49286 2/20 0.36
TP53 P04637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27718881 0.86 MAPT (0.43) ALDH1A1MAPTKDM4EKMT2AATM
SCHEMBL27718913 0.78 ALDH1A1 (0.44) ALDH1A1MAPTKDM4EKMT2AATM
SCHEMBL29685513 0.77 MTNR1A (0.47) ALDH1A1KDM4EKMT2AATMHSD17B10
SCHEMBL3573582 0.77 MTNR1A (0.47) ALDH1A1KDM4EKMT2AATMHSD17B10
SCHEMBL25668856 0.76 MAPT (0.55) MAPTKMT2A
SCHEMBL905742 0.73 ALDH1A1 (0.49) ALDH1A1MAPTKDM4EHPGDHSD17B10
SCHEMBL31596506 0.71 MTNR1A (0.50) ALDH1A1MAPTKDM4EKMT2ASMN1; SMN2
SCHEMBL905702 0.71 MTNR1A (0.43) ALDH1A1KMT2ANPC1RAB9AALOX15
SCHEMBL17846702 0.71 MTNR1A (0.43) ALDH1A1MAPTKDM4EHPGDHSD17B10
SCHEMBL28853339 0.71 MTNR1A (0.40) ALDH1A1MAPTKDM4EKMT2AATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101160307-A Benzoxazole carboxamides for the treatment of CINV and IBS-D AMR TECHNOLOGY INC (US) 2008-04-09 CN disclosed