SCHEMBL2769862

SCHEMBL2769862

Oc1c(Cl)cc(-c2cc(Cl)ccc2Cl)cc1Cl

nearest known ligand 0.54

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TTR P02766 1/20 0.54
TSHR P16473 3/20 0.48
HSD17B10 Q99714 3/20 0.48
ALDH1A1 P00352 3/20 0.48
CYP3A4 P08684 2/20 0.48
TDP1 Q9NUW8 1/20 0.48
RECQL P46063 1/20 0.48
AHR P35869 3/20 0.47
TP53 P04637 2/20 0.42
HTR2B P41595 1/20 0.41
PDE4D Q08499 1/20 0.41
CNR2 P34972 2/20 0.40
RPS6KA3 P51812 1/20 0.40
THRB P10828 1/20 0.39
PTPN11 Q06124 1/20 0.39
IDO1 P14902 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4450644 0.82 AHR (0.68) TSHRHSD17B10ALDH1A1CYP3A4TDP1
SCHEMBL4459046 0.79 TP53 (0.48) TSHRHSD17B10ALDH1A1CYP3A4TDP1
SCHEMBL2280325 0.78 HSD17B10 (0.48) TSHRHSD17B10ALDH1A1CYP3A4TDP1
SCHEMBL4445026 0.77 AHR (0.67) TSHRHSD17B10ALDH1A1CYP3A4TDP1
SCHEMBL28330002 0.77 HSD17B10 (0.46) TSHRHSD17B10ALDH1A1CYP3A4TDP1
SCHEMBL2473835 0.77 AHR (0.54) TSHRHSD17B10ALDH1A1CYP3A4TDP1
SCHEMBL440944 0.75 TP53 (0.61) TSHRHSD17B10ALDH1A1CYP3A4TDP1
SCHEMBL29364307 0.75 TP53 (0.61) TSHRHSD17B10ALDH1A1CYP3A4TDP1
SCHEMBL3566720 0.75 TTR (0.70) TTRTSHRHSD17B10ALDH1A1CYP3A4
SCHEMBL463542 0.74 AHR (0.72) TTRTSHRHSD17B10ALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260063601-A1 PLASMA METABOLOME AS A PREDICTOR OF BIOLOGICAL AGING THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY (US) 2026-03-05 US disclosed
US-12080432-B1 Plasma metabolome as a predictor of biological aging THE REGENTS OF THE UNIVERSITY OF COLORADO (US) 2024-09-03 US disclosed
CN-114660033-A Method for rapidly detecting thyroxine T4 based on fluorescence resonance transfer 武汉海关技术中心 2022-06-24 CN disclosed
EP-1790216-B1 METHOD OF DETECTING ESTROGEN-LIKE SUBSTANCE BY USING PLANT UNIV HOKKAIDO NAT UNIV CORP (JP) 2010-04-21 EP disclosed
US-20080199858-A1 Method for Detecting Estrogen-Like Chemicals by Plant NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) 2008-08-21 US disclosed
EP-1790216-A1 METHOD OF DETECTING ESTROGEN-LIKE SUBSTANCE BY USING PLANT National University Corporation Hokkaido University (JP) 2007-05-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260063601-A1 PLASMA METABOLOME AS A PREDICTOR OF BIOLOGICAL AGING PLPBP, PLCG1, PLA2G1B TTR 437/4885TSHR 2218/4885HSD17B10 823/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.