Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 8/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14601364 | 0.81 | OPRM1 (0.76) | OPRL1OPRM1OPRK1MAOAMAOB | |
| SCHEMBL25516914 | 0.80 | OPRL1 (0.46) | OPRL1OPRM1OPRK1CA12NPSR1 | |
| SCHEMBL2464748 | 0.76 | OPRM1 (0.64) | OPRL1OPRM1OPRK1MAOAMAOB | |
| SCHEMBL7618708 | 0.75 | ALDH1A1 (0.50) | OPRM1KMT2AALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL8366796 | 0.75 | OPRM1 (0.49) | OPRL1OPRM1OPRK1 | |
| SCHEMBL5569970 | 0.74 | OPRM1 (0.62) | OPRL1OPRM1OPRK1MAOAMAOB | |
| Hydrochloric Acid SCHEMBL11729597 | 0.74 | OPRL1 (0.62) | OPRL1OPRM1OPRK1MAOAMAOB | |
| SCHEMBL23779016 | 0.74 | HDAC4 (0.40) | NPC1RAB9ACA12CA9KMT2A | |
| SCHEMBL9833979 | 0.73 | KMT2A (0.48) | OPRL1OPRM1OPRK1KMT2AALDH1A1 | |
| SCHEMBL2183965 | 0.73 | OPRM1 (0.42) | OPRL1OPRM1OPRK1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101146530-B | 3, 4-substituted pyrrolidine derivatives for the treatment of hypertension | NOVARTIS AG | 2011-05-18 | — | — | CN | disclosed |
| CN-101146530-A | 3, 4-substituted pyrrolidine derivatives for the treatment of hypertension | NOVARTIS AG (CH) | 2008-03-19 | — | — | CN | disclosed |