Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.39 |
| ▸ | HPGD | P15428 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28768571 | 0.87 | ALOX5 (0.47) | ALOX5ALDH1A1HPGDLMNAUSP2 | |
| SCHEMBL27699850 | 0.87 | ALOX5 (0.46) | ALOX5ALDH1A1HPGDLMNAKDM4E | |
| SCHEMBL27720312 | 0.85 | ALOX5 (0.41) | ALOX5ALDH1A1HPGDLMNAKDM4E | |
| SCHEMBL27699684 | 0.83 | ALOX5 (0.56) | ALOX5ALDH1A1HPGDLMNAKDM4E | |
| SCHEMBL4076109 | 0.81 | ALOX5 (0.58) | ALOX5ALDH1A1HPGDLMNAKDM4E | |
| SCHEMBL27720330 | 0.76 | ALOX5 (0.55) | ALOX5ALDH1A1HPGDLMNAKDM4E | |
| SCHEMBL27720323 | 0.74 | ALOX5 (0.55) | ALOX5ALDH1A1HPGDLMNAKDM4E | |
| SCHEMBL27720333 | 0.73 | ALOX5 (0.50) | ALOX5ALDH1A1HPGDKDM4EUSP2 | |
| SCHEMBL27720329 | 0.73 | ALDH1A1 (0.43) | ALDH1A1HPGDLMNAKDM4EHTT | |
| SCHEMBL4084878 | 0.72 | ALOX5 (0.61) | ALOX5ALDH1A1HPGDLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101146802-A | Thiadiazole-substituted coumarin derivatives and their use as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA LTD (CA) | 2008-03-19 | — | — | CN | claimed |