Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 7/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SNCA | P37840 | 2/20 | 0.43 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31419932 | 0.77 | TGM2 (0.66) | EGFRPDPK1KDRPDGFRBPDGFRA | |
| SCHEMBL5325427 | 0.77 | TGM2 (0.66) | EGFRPDPK1KDRPDGFRBPDGFRA | |
| SCHEMBL9094472 | 0.73 | ACVR1 (0.64) | EGFRPDPK1KDRPDGFRBPDGFRA | |
| SCHEMBL10559920 | 0.71 | EGFR (0.64) | EGFRPDPK1KDRPDGFRBPDGFRA | |
| SCHEMBL177986 | 0.66 | MAOA (0.56) | EGFRMAOAMAOBESR1UGT1A1 | |
| SCHEMBL30828317 | 0.66 | MAOA (0.56) | EGFRMAOAMAOBESR1UGT1A1 | |
| SCHEMBL5323182 | 0.66 | CES1 (0.60) | EGFRPDPK1TGM2CES1MAOA | |
| SCHEMBL22910640 | 0.66 | PDE3B (0.58) | EGFRPDPK1KDRPDGFRBPDGFRA | |
| SCHEMBL10866889 | 0.65 | PDPK1 (0.65) | EGFRPDPK1KDRPDGFRBPDGFRA | |
| SCHEMBL11748758 | 0.61 | CHEK1 (0.47) | EGFRPDPK1KDRPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101157687-A | 2-indole ketone compound, preparation and uses thereof | UNIV EAST CHINA NORMAL (CN) | 2008-04-09 | — | — | CN | claimed |
| CN-101157687-A | 2-indole ketone compound, preparation and uses thereof | UNIV EAST CHINA NORMAL (CN) | 2008-04-09 | — | — | CN | disclosed |