Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 5/20 | 0.55 |
| ▸ | PPARG | P37231 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | PTGIR | P43119 | 2/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7110156 | 0.90 | PPARA (0.55) | PPARAPPARGPSEN1PSEN2APH1B | |
| SCHEMBL7421105 | 0.86 | CYP4F2 (0.52) | PPARAPPARGMEN1KMT2AGAA | |
| SCHEMBL2769640 | 0.86 | MTNR1A (0.50) | PPARAPPARGKMT2AGAAMAPT | |
| SCHEMBL2789633 | 0.86 | PPARA (0.49) | PPARAPPARG | |
| SCHEMBL7643204 | 0.85 | ACHE (0.52) | PPARAPPARGMEN1KMT2AGAA | |
| SCHEMBL2768428 | 0.85 | PPARA (0.48) | PPARAPPARGKMT2AMAPTCYP2C9 | |
| SCHEMBL5472921 | 0.84 | PLA2G4B (0.57) | PPARAPPARGPSEN1PSEN2APH1B | |
| SCHEMBL29642028 | 0.83 | TSHR (0.49) | PPARAPPARGGAAPSEN1PSEN2 | |
| SCHEMBL6216172 | 0.83 | TSHR (0.49) | PPARAPPARGGAAPSEN1PSEN2 | |
| SCHEMBL8521889 | 0.83 | CALM1 (0.52) | PPARAPPARGGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888303-B1 | SYNTHETIC DERIVATIVES OF RAPAMYCIN AS MULTIMERIZING AGENTS FOR CHIMERIC PROTEINS WITH IMMUNOPHILIN-DERIVED DOMAINS | ARIAD PHARMA INC (US) | 2010-04-21 | — | — | EP | disclosed |