Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 5/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | CLK2 | P49760 | 3/20 | 0.41 |
| ▸ | HIPK4 | Q8NE63 | 3/20 | 0.41 |
| ▸ | SRPK1 | Q96SB4 | 3/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.41 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.41 |
| ▸ | NEK4 | P51957 | 1/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5747725 | 0.91 | MALT1 (0.46) | HPGDSATRMALT1SRCMAP4K4 | |
| SCHEMBL6478363 | 0.84 | CSF1R (0.44) | HPGDSKDRCLK2HIPK4SRPK1 | |
| SCHEMBL7160706 | 0.83 | MALT1 (0.45) | KDRMALT1CSF1R | |
| SCHEMBL31554483 | 0.83 | MALT1 (0.45) | KDRMALT1CSF1R | |
| SCHEMBL9384100 | 0.80 | MALT1 (0.43) | KDRATRMALT1SRCMAP4K4 | |
| SCHEMBL2952668 | 0.79 | LMNA (0.41) | HPGDSKDRCLK2HIPK4SRPK1 | |
| SCHEMBL21561044 | 0.78 | MALT1 (0.57) | KDRATRMALT1MAP4K4AURKB | |
| SCHEMBL14598625 | 0.76 | TDP1 (0.51) | ATR | |
| SCHEMBL9377882 | 0.75 | MALT1 (0.42) | KDRATRMALT1MAP4K4AURKB | |
| SCHEMBL28708582 | 0.74 | ATR (0.46) | STK17AMKNK2ATRMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101035780-A | Substituted nitrogen-containing six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating pain | MERCK SHARP & DOHME (GB) | 2007-09-12 | — | — | CN | disclosed |