Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 8/20 | 0.45 |
| ▸ | EGFR | P00533 | 7/20 | 0.45 |
| ▸ | CSF1R | P07333 | 9/20 | 0.44 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31554483 | 1.00 | MALT1 (0.45) | MALT1KDREGFRCSF1RENPP1 | |
| SCHEMBL6345971 | 0.84 | EHMT2 (0.53) | KDR | |
| SCHEMBL5747725 | 0.83 | MALT1 (0.46) | MALT1 | |
| SCHEMBL27700692 | 0.83 | HPGDS (0.42) | MALT1KDRCSF1R | |
| SCHEMBL25631419 | 0.83 | MALT1 (0.49) | MALT1KDREGFRCSF1RNUDT1 | |
| SCHEMBL9384100 | 0.81 | MALT1 (0.43) | MALT1KDREGFR | |
| SCHEMBL23515535 | 0.81 | MET (0.41) | KDRCSF1RENPP1NUDT1 | |
| SCHEMBL21375591 | 0.80 | PDGFRA (0.55) | KDREGFR | |
| SCHEMBL21561044 | 0.80 | MALT1 (0.57) | MALT1KDREGFR | |
| SCHEMBL3631578 | 0.79 | ATR (0.44) | KDREGFRDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115362150-A | ENPP1 inhibitor, composition and application thereof | 贝达药业股份有限公司 | 2022-11-18 | — | — | CN | disclosed |
| US-6638945-B1 | Pharmaceutical compositions and methods of treatment of proliferative disease such as cancer using said inhibitors of specific kinase enzymes, especially MEK enzymes, as well as novel quinoline derivatives as antigrowth agents | ASTRAZENECA AB (SE) | 2003-10-28 | — | — | US | disclosed |
| EP-1178965-B1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | ASTRAZENECA AB (SE) | 2003-09-24 | — | — | EP | disclosed |
| EP-1178965-A1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | AstraZeneca AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000068199-A1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | ASTRAZENECA AB (SE) | 2000-11-16 | — | — | WO | disclosed |