Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 4/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21561044 | 0.88 | MALT1 (0.57) | MALT1MAP4K4LCKP2RX3ATR | |
| SCHEMBL5747725 | 0.87 | MALT1 (0.46) | MALT1MAP4K4ATRMEN1KMT2A | |
| SCHEMBL9377882 | 0.85 | MALT1 (0.42) | MALT1MAP4K4LCKP2RX3ATR | |
| SCHEMBL31554483 | 0.81 | MALT1 (0.45) | MALT1EGFRKDR | |
| SCHEMBL7160706 | 0.81 | MALT1 (0.45) | MALT1EGFRKDR | |
| SCHEMBL15450948 | 0.81 | HTR1A (0.54) | MAP4K4LCKATRAAK1PIK3CD | |
| SCHEMBL27700692 | 0.80 | HPGDS (0.42) | MALT1MAP4K4ATRSRCKDR | |
| SCHEMBL21494399 | 0.77 | MALT1 (0.50) | MALT1MAP4K4LCKAAK1MAPK1 | |
| SCHEMBL31413740 | 0.76 | AAK1 (0.47) | MALT1MAP4K4P2RX3AAK1PIK3CD | |
| SCHEMBL9724144 | 0.75 | LMNA (0.48) | LCKPKMMEN1THRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0318225-B1 | 6-Aryl aminomethyl quinoline derivatives and their use as anti-tumour agents | ICI PLC (GB) | 1994-03-16 | — | — | EP | disclosed |
| US-5112837-A | Inhibitors of thymidylate synthetase enzyme | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-05-12 | — | — | US | disclosed |
| EP-0318225-A2 | 6-Aryl aminomethyl quinoline derivatives and their use as anti-tumour agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-05-31 | — | — | EP | disclosed |