Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SUCNR1 | Q9BXA5 | 6/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6033545 | 0.82 | TRPV1 (0.61) | TRPV1 | |
| SCHEMBL6033649 | 0.79 | TRPV1 (0.54) | TRPV1MAPK3 | |
| SCHEMBL6033641 | 0.75 | TRPV1 (0.54) | TRPV1MAPK3 | |
| SCHEMBL27681512 | 0.74 | CCR1 (0.36) | ALDH1A1KDM4ELMNA | |
| SCHEMBL27681517 | 0.73 | TRPV1 (0.42) | TRPV1MIFALDH1A1SUCNR1KDM4E | |
| SCHEMBL5801087 | 0.72 | TRPV1 (0.56) | TRPV1 | |
| SCHEMBL5809097 | 0.71 | TRPV1 (0.57) | TRPV1 | |
| SCHEMBL1089189 | 0.67 | ALDH1A1 (0.55) | MIFALDH1A1KDM4EMEN1LMNA | |
| SCHEMBL27700674 | 0.65 | MTOR (0.37) | TRPV1 | |
| SCHEMBL18806846 | 0.65 | ALDH1A1 (0.48) | MIFALDH1A1SUCNR1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101035780-A | Substituted nitrogen-containing six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating pain | MERCK SHARP & DOHME (GB) | 2007-09-12 | — | — | CN | claimed |
| CN-101035780-A | Substituted nitrogen-containing six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating pain | MERCK SHARP & DOHME (GB) | 2007-09-12 | — | — | CN | disclosed |