SCHEMBL1089189

SCHEMBL1089189

c1cnc2nc(-c3ccc4cccnc4n3)ccc2c1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.55
LMNA P02545 4/20 0.53
KDM4E B2RXH2 3/20 0.53
MEN1 O00255 2/20 0.53
KMT2A Q03164 2/20 0.53
MIF P14174 1/20 0.53
HTT P42858 3/20 0.50
TP53 P04637 2/20 0.50
HSP90AA1 P07900 2/20 0.50
ALOX15 P16050 2/20 0.50
CCR1 P32246 2/20 0.50
CCR5 P51681 2/20 0.50
CCR8 P51685 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
TDP1 Q9NUW8 2/20 0.50
CYP3A4 P08684 2/20 0.50
GMNN O75496 1/20 0.50
MMP2 P08253 1/20 0.50
CYP2D6 P10635 1/20 0.50
MAPT P10636 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29707169 0.93 KDM4E (0.52) ALDH1A1LMNAKDM4EMEN1KMT2A
SCHEMBL21365377 0.93 KDM4E (0.52) ALDH1A1LMNAKDM4EMEN1KMT2A
SCHEMBL10067161 0.89 KDM4E (0.59) ALDH1A1LMNAKDM4EMEN1KMT2A
SCHEMBL23418270 0.88 ALDH1A1 (0.54) ALDH1A1LMNAKDM4EMEN1KMT2A
SCHEMBL29484745 0.88 ALDH1A1 (0.54) ALDH1A1LMNAKDM4EMEN1KMT2A
SCHEMBL31069689 0.88 LMNA (0.61) ALDH1A1LMNAKDM4EMEN1KMT2A
SCHEMBL18806846 0.87 ALDH1A1 (0.48) ALDH1A1LMNAKDM4EMEN1KMT2A
SCHEMBL19705286 0.86 CYP3A4 (0.48) ALDH1A1LMNAKDM4EMEN1KMT2A
SCHEMBL5309600 0.85 KMT2A (0.50) ALDH1A1LMNAKDM4EMEN1KMT2A
SCHEMBL22824613 0.84 MIF (0.43) ALDH1A1LMNAKDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 141 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12171909-B2 Implants having a drug load of an oxysterol and methods of use WARSAW ORTHOPEDIC, INC. (US) 2024-12-24 US disclosed
US-12171665-B2 Compression resistant implants including an oxysterol and methods of use WARSAW ORTHOPEDIC, INC. (US) 2024-12-24 US disclosed
CN-112334520-B Polyamide resin film and resin laminate using same 株式会社LG化学 2024-04-02 CN disclosed
CN-112204074-B Polyamide resin, method for producing same, and polyamide film and resin laminate comprising same 株式会社LG化学 2024-01-26 CN disclosed
CN-117413048-A Microcarrier, cell complex using same, and medical composition, cosmetic composition, medical product, and cosmetic product 株式会社LG化学 2024-01-16 CN disclosed
CN-113207294-B Polymer resin composition, and polymer film and resin laminate using same 株式会社LG化学 2023-10-20 CN disclosed
CN-112204083-B Polyamide resin film and resin laminate using same 株式会社LG化学 2023-08-18 CN disclosed
CN-112243448-B Polyamide resin, and polymer film and resin laminate using same 株式会社LG化学 2023-07-25 CN disclosed
US-20230166003-A1 IMPLANTS HAVING A DRUG LOAD OF AN OXYSTEROL AND METHODS OF USE WARSAW ORTHOPEDIC, INC. (US) 2023-06-01 US disclosed
CN-112262171-B Polyamide resin, and polymer film and resin laminate using same 株式会社LG化学 2023-04-28 CN disclosed
US-6811979-B2 NUCLEOTIDE DERIVATIVE FOR USE IN SEQUENCE DETERMINATION OF NUCLEIC ACID MOLECULE APPLERA CORPORATION 2004-11-02 US disclosed
EP-1141137-B1 WATER-SOLUBLE RHODAMINE DYES AND CONJUGATES THEREOF APPLERA CORP (US) 2003-10-08 EP disclosed
EP-1317464-A2 FLUORESCENT NUCLEOBASE CONJUGATES HAVING ANIONIC LINKERS Applera Corporation (US) 2003-06-11 EP disclosed
US-20030055257-A1 Water-soluble rhodamine dye conjugates APPLERA CORPORATION (US) 2003-03-20 US disclosed
US-20020102590-A1 Fluorescent nucleobase conjugates having anionic linkers PE CORPORATION (NY) (US) 2002-08-01 US disclosed
WO-2002030944-A2 FLUORESCENT NUCLEOBASE CONJUGATES HAVING ANIONIC LINKERS APPLERA CORPORATION (US) 2002-04-18 WO disclosed
US-6372907-B1 LABELLED RHODAMINE DYE-POLYPEPTIDE CONJUGATE, OR SALT THEREOF, COMPRISING RHODAMINE-TYPE PARENT XANTHENE RING SUBSTITUTED AT XANTHENE C-9 CARBON WITH SUBSTITUTED PHENYL RING APPTERA CORPORATION 2002-04-16 US disclosed
EP-1141137-A1 WATER-SOLUBLE RHODAMINE DYES AND CONJUGATES THEREOF Applera Corporation (US) 2001-10-10 EP disclosed
WO-2001032783-A1 WATER-SOLUBLE RHODAMINE DYES AND CONJUGATES THEREOF APPLERA CORPORATION (US) 2001-05-10 WO disclosed
US-6191278-B1 COMPRISING A RHODAMINE-TYPE PARENT RING HAVING ATTACHED TO THE XANTHENE C9 CARBON A PHENYL GROUP THAT IS SUBSTITUTED WITH CARBOXY OR SULFONATE GROUP, ONE TO THREE AMINOPYRIDINIUM GROUPS AND AN ALKYL- OR ARYLTHIO, AND OPTIONALLY OTHER GROUPS PE CORPORATION 2001-02-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12171909-B2 Implants having a drug load of an oxysterol and methods of use SOST, CYP17A1, HSD17B7 ALDH1A1 2822/4885LMNA 1681/4885KDM4E 416/4885
US-20230166003-A1 IMPLANTS HAVING A DRUG LOAD OF AN OXYSTEROL AND METHODS OF USE SOST, CYP17A1, HSD17B7 ALDH1A1 2822/4885LMNA 1681/4885KDM4E 416/4885
US-20030055257-A1 Water-soluble rhodamine dye conjugates SLC43A3, ABCG2, TARBP1 ALDH1A1 1349/4885LMNA 2551/4885KDM4E 4494/4885
US-20020102590-A1 Fluorescent nucleobase conjugates having anionic linkers DNTT, DUT, NT5C3B ALDH1A1 2642/4885LMNA 1676/4885KDM4E 1295/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.