Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | TDO2 | P48775 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MIF | P14174 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2769156 | 0.84 | ALDH1A1 (0.38) | AKR1B1ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL2768029 | 0.82 | AKR1B1 (0.50) | AKR1B1ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL2770536 | 0.75 | MAPT (0.47) | AKR1B1ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL2770191 | 0.69 | ALDH1A1 (0.40) | ALDH1A1MAPTPOLBKDM4EL3MBTL1 | |
| SCHEMBL2769430 | 0.69 | POLB (0.38) | ALDH1A1POLBKDM4EHPGDHSD17B10 | |
| SCHEMBL18079049 | 0.68 | CES1 (0.42) | AKR1B1ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL8473291 | 0.68 | PNMT (0.54) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9261308 | 0.68 | TTR (0.40) | ALDH1A1MAPTKMT2AMEN1IDO1 | |
| SCHEMBL24353347 | 0.68 | CES1 (0.61) | PKMCES1MIFTDP1L3MBTL1 | |
| SCHEMBL23723961 | 0.67 | MAOA (0.49) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479670-B1 | NOVEL FUSED RING INDAZOLE COMPOUNDS | EISAI R&D MAN CO LTD (JP) | 2010-04-21 | — | — | EP | disclosed |
| EP-1479670-B1 | NOVEL FUSED RING INDAZOLE COMPOUNDS | EISAI R&D MAN CO LTD (JP) | 2010-04-21 | — | — | EP | disclosed |
| US-7390797-B2 | Fused indazole compounds | EISAI CO., LTD. (JP) | 2008-06-24 | — | — | US | disclosed |
| US-7390797-B2 | Fused indazole compounds | EISAI CO., LTD. (JP) | 2008-06-24 | — | — | US | disclosed |
| US-7390797-B2 | Fused indazole compounds | EISAI CO., LTD. (JP) | 2008-06-24 | — | — | US | disclosed |
| US-20060111419-A1 | Novel fused indazole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2006-05-25 | — | — | US | disclosed |
| EP-1479670-A1 | NOVEL FUSED RING INDAZOLE COMPOUNDS | Eisai Co., Ltd. (JP) | 2004-11-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060111419-A1 | Novel fused indazole compounds | MAP2K3, MAP3K11, MAP2K2 | AKR1B1 947/4885ALDH1A1 1751/4885MAPT 2110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.