Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4274235 | 0.91 | ALDH1A1 (0.53) | ALOX15HPGDLMNASMN1; SMN2MAPT | |
| SCHEMBL8063146 | 0.89 | ALOX15 (0.63) | ALOX15HPGDLMNASMN1; SMN2MAPT | |
| SCHEMBL9033681 | 0.87 | ALOX15 (0.60) | ALOX15HPGDLMNASMN1; SMN2MAPT | |
| SCHEMBL396614 | 0.82 | HPGD (0.64) | ALOX15HPGDLMNASMN1; SMN2MAPT | |
| SCHEMBL30065410 | 0.82 | HPGD (0.64) | ALOX15HPGDLMNASMN1; SMN2MAPT | |
| SCHEMBL28611035 | 0.80 | HPGD (0.62) | ALOX15HPGDLMNASMN1; SMN2MAPT | |
| SCHEMBL10202005 | 0.78 | ALOX15 (0.79) | ALOX15HPGDLMNASMN1; SMN2MAPT | |
| SCHEMBL376962 | 0.78 | ALOX15 (0.47) | ALOX15HPGDLMNASMN1; SMN2MAPT | |
| SCHEMBL297225 | 0.76 | ALOX15 (1.00) | ALOX15HPGDLMNASMN1; SMN2MAPT | |
| SCHEMBL13036676 | 0.75 | ALOX15 (0.60) | ALOX15HPGDLMNASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101115742-B | Heterocycle derivatives as histone deacetylase (hdac) inhibitors | ANGELETTI P IST RICHERCHE BIO | 2011-06-22 | — | — | CN | disclosed |
| CN-101115742-A | Heterocycle derivatives as histone deacetylase (hdac) inhibitors | ANGELETTI P IST RICHERCHE BIO (IT) | 2008-01-30 | — | — | CN | disclosed |