Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 2/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 2/20 | 0.35 |
| ▸ | MPL | P40238 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
| ▸ | FURIN | P09958 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | OGA | O60502 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.32 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28768832 | 0.91 | MPL (0.42) | MGLLMPLAOC3CXCR3 | |
| SCHEMBL27701424 | 0.83 | CXCR3 (0.38) | MPLAOC3SCN9ACXCR3 | |
| SCHEMBL27701427 | 0.81 | GRM2 (0.35) | MPLCXCR3GRM2 | |
| SCHEMBL27701415 | 0.79 | SCN9A (0.34) | MPLSCN9A | |
| SCHEMBL27701488 | 0.79 | HRH4 (0.35) | UCHL1USP30PTPN11GRM2 | |
| SCHEMBL27701416 | 0.77 | KMT2A (0.37) | AOC3 | |
| SCHEMBL27682276 | 0.76 | SCN9A (0.36) | MPLSCN9ACXCR3 | |
| SCHEMBL27701423 | 0.75 | PRKCB (0.34) | HDAC2 | |
| SCHEMBL907961 | 0.75 | KHK (0.39) | MGLLMPLCXCR3 | |
| SCHEMBL907898 | 0.73 | MPL (0.45) | MPLAOC3CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101014587-A | Substituted biaryl piperazinyl-pyridine analogues | NEUROGEN CORP (US) | 2007-08-08 | — | — | CN | claimed |