Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL156136 | 0.98 | — | — | |
| SCHEMBL29627845 | 0.98 | — | — | |
| SCHEMBL5763859 | 0.82 | MAOB (0.37) | CHEK1AREGLN2GBA1MAOA | |
| SCHEMBL2008653 | 0.81 | CHEK1 (0.45) | CHEK1ALDH1A1EGLN2PTGESMEN1 | |
| SCHEMBL4756228 | 0.74 | — | — | |
| SCHEMBL20155217 | 0.74 | CHEK1 (0.66) | CHEK1AR | |
| SCHEMBL30270074 | 0.73 | CHRNB2 (0.41) | CHEK1KDM4EALDH1A1AR | |
| SCHEMBL20644559 | 0.73 | CHRNB2 (0.41) | CHEK1KDM4EALDH1A1AR | |
| SCHEMBL12630708 | 0.71 | CHEK1 (0.51) | CHEK1EGLN2 | |
| SCHEMBL1026572 | 0.71 | ALDH1A1 (0.48) | CHEK1KDM4EALDH1A1EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101163694-A | Imidaz0l0-5-yl-2-anil0-pyrimidines as agents for the inhibition of cell proliferation | ASTRAZENECA AB ASTRAZENECA UK (SE) | 2008-04-16 | — | — | CN | disclosed |