SCHEMBL27705358

SCHEMBL27705358

O=C(O)/C=C/C=Cc1ccc(-c2ccccc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC2 Q92769 5/20 0.58
HDAC6 Q9UBN7 4/20 0.55
HDAC1 Q13547 3/20 0.55
HDAC8 Q9BY41 3/20 0.55
HDAC3 O15379 2/20 0.55
HDAC4 P56524 2/20 0.55
HDAC7 Q8WUI4 2/20 0.55
HDAC10 Q969S8 2/20 0.55
HDAC11 Q96DB2 2/20 0.55
HDAC9 Q9UKV0 2/20 0.55
HDAC5 Q9UQL6 2/20 0.55
HCAR2 Q8TDS4 2/20 0.55
TNKS O95271 1/20 0.55
TNKS2 Q9H2K2 1/20 0.55
MAOB P27338 3/20 0.50
CYP1A2 P05177 1/20 0.49
HSD17B10 Q99714 1/20 0.49
FFAR1 O14842 1/20 0.49
CA1 P00915 2/20 0.48
TP53 P04637 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1232945 1.00 HDAC2 (0.58) HDAC2HDAC6HDAC1HDAC8HDAC3
SCHEMBL1232946 1.00 HDAC2 (0.58) HDAC2HDAC6HDAC1HDAC8HDAC3
Juarezic Acid SCHEMBL144681 0.88 HDAC3 (0.71) HDAC2HDAC6HDAC1HDAC8HDAC3
Juarezic Acid SCHEMBL15119 0.88 HDAC3 (0.71) HDAC2HDAC6HDAC1HDAC8HDAC3
Juarezic Acid SCHEMBL11522747 0.88 HDAC3 (0.71) HDAC2HDAC6HDAC1HDAC8HDAC3
Juarezic Acid SCHEMBL436113 0.88 HDAC3 (0.71) HDAC2HDAC6HDAC1HDAC8HDAC3
Juarezic Acid SCHEMBL144680 0.88 HDAC3 (0.71) HDAC2HDAC6HDAC1HDAC8HDAC3
Juarezic Acid SCHEMBL474728 0.88 HDAC3 (0.71) HDAC2HDAC6HDAC1HDAC8HDAC3
Juarezic Acid SCHEMBL560728 0.86 HDAC3 (0.68) HDAC2HDAC6HDAC1HDAC8HDAC3
Juarezic Acid SCHEMBL3280210 0.86 HDAC3 (0.68) HDAC2HDAC6HDAC1HDAC8HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102993051-A Biphenyl and naphthyl-phenyl hydroxamic acid derivatives SIGMA TAU IND FARMACEUTI 2013-03-27 CN disclosed
CN-101198586-A Biphenyl and naphthyl-phenyl hydroxamic acid derivatives SIGMA TAU IND FARMACEUTI (IT) 2008-06-11 CN disclosed