Juarezic Acid

Juarezic Acid

SCHEMBL560728

Cl.O=C(O)C=CC=Cc1ccccc1

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Juarezic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 known ✓ O15379 3/20 0.68
HDAC4 known ✓ P56524 3/20 0.68
HDAC1 known ✓ Q13547 3/20 0.68
HDAC2 known ✓ Q92769 3/20 0.68
HDAC8 known ✓ Q9BY41 3/20 0.68
HDAC6 known ✓ Q9UBN7 3/20 0.68
HDAC7 known ✓ Q8WUI4 2/20 0.68
HDAC10 known ✓ Q969S8 2/20 0.68
HDAC11 known ✓ Q96DB2 2/20 0.68
HDAC9 known ✓ Q9UKV0 2/20 0.68
HDAC5 known ✓ Q9UQL6 2/20 0.68
MAOB known ✓ P27338 8/20 0.61
MAOA known ✓ P21397 1/20 0.54
GLA known ✓ P06280 1/20 0.52
BCHE known ✓ P06276 1/20 0.50
ACHE known ✓ P22303 1/20 0.50
TNKS O95271 1/20 0.68
HCAR2 Q8TDS4 1/20 0.68
TNKS2 Q9H2K2 1/20 0.68
ALDH1A1 P00352 3/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Juarezic Acid SCHEMBL15119 0.98 HDAC3 (0.71) HDAC3HDAC4HDAC1HDAC2HDAC8
Juarezic Acid SCHEMBL436113 0.98 HDAC3 (0.71) HDAC3HDAC4HDAC1HDAC2HDAC8
Juarezic Acid SCHEMBL474728 0.98 HDAC3 (0.71) HDAC3HDAC4HDAC1HDAC2HDAC8
Juarezic Acid SCHEMBL11522747 0.98 HDAC3 (0.71) HDAC3HDAC4HDAC1HDAC2HDAC8
Juarezic Acid SCHEMBL144680 0.98 HDAC3 (0.71) HDAC3HDAC4HDAC1HDAC2HDAC8
Juarezic Acid SCHEMBL144681 0.98 HDAC3 (0.71) HDAC3HDAC4HDAC1HDAC2HDAC8
Juarezic Acid SCHEMBL3280210 0.96 HDAC3 (0.68) HDAC3HDAC4HDAC1HDAC2HDAC8
Juarezic Acid SCHEMBL30239689 0.96 HDAC3 (0.68) HDAC3HDAC4HDAC1HDAC2HDAC8
Juarezic Acid SCHEMBL2335383 0.96 HDAC3 (0.68) HDAC3HDAC4HDAC1HDAC2HDAC8
Juarezic Acid SCHEMBL5399197 0.96 HDAC3 (0.68) HDAC3HDAC4HDAC1HDAC2HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-56122030-A None JP disclosed
CN-110352226-B Water-based adhesives composed of dispersed polymer and emulsified silicone polymer 诺莱克斯股份公司 2023-11-07 CN disclosed
US-8878169-B2 Photocurable polymeric materials and related electronic devices POLYERA CORPORATION (US) 2014-11-04 US disclosed
US-20130200345-A1 Photocurable Polymeric Materials and Related Electronic Devices USINVEST LLC 2013-08-08 US disclosed
US-8420698-B2 Histone deacetylase inhibitors ERRANT GENE THERAPEUTICS, LLC (US) 2013-04-16 US disclosed
US-20120035257-A1 Histone Deacetylase Inhibitors ERRANT GENE THERAPEUTICS, LLC 2012-02-09 US disclosed
US-20110287535-A1 Histone Deacetylase Inhibitors ERRANT GENE THERAPEUTICS, LLC 2011-11-24 US disclosed
US-20110288168-A1 HISTONE DEACETYLASE INHIBITORS ERRANT GENE THERAPEUTICS, LLC 2011-11-24 US disclosed
US-8026280-B2 For therapy of cancer, hematological disorders, e.g., hemoglobinopathies, and genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy. ERRANT GENE THERAPEUTICS, LLC (US) 2011-09-27 US disclosed
US-7902259-B2 with zinc-binding activities; 5-phenyl-2,4,-pentadienoyl hydroxamic acid; gene expression inhibitor; anticarcinogenic, antitumor, antiprotozoa agent, viricide; hematological disorders, hemoglobinopathies, genetic related metabolic disorders, cystic fibrosis ERRANT GENE THERAPEUTICS, LLC (US) 2011-03-08 US disclosed
US-20020099089-A1 Carboxylic acid amides, pharmaceutical compositions containing these compounds, their use and preparation BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2002-07-25 US disclosed
US-6362210-B1 ANTITUMOR, ANTICANCER AGENT BOEHRINGER INGELHEIM PHARMA KG (DE) 2002-03-26 US disclosed
US-5112924-A Multilayer fabric, fiber or particle composite of improved heat resistance and high strength HERCULES INCORPORATED (US) 1992-05-12 US disclosed
US-5096766-A Prepregs HERCULES INCORPORATED (US) 1992-03-17 US disclosed
US-4946908-A DAMAGE TOLERANCE, SHEAR STRENGTH, THERMOCRACKING HERCULES INCORPORATED (US) 1990-08-07 US disclosed
EP-0363524-A1 Bismaleimide compositions containing high glass transition temperature and soluble reactive oligomers and composites prepared therefrom HERCULES INCORPORATED (US) 1990-04-18 EP disclosed
JP-S56122030-A PHOTOSENSITIVE RESIN COMPOSITION DEVELOPABLE WITH AQUEOUS ALKALI SOLUTION DAICEL CHEM IND LTD 1981-09-25 JP disclosed
US-4264713-A COMPRISING LIGHT SENSITIVE POLYMERS OF AN UNSATURATED POLYESTER AND AN ACRYLIC POLYMER WITH UNSATURATED SIDE CHAINS FUJI PHOTO FILM CO., LTD. (JP) 1981-04-28 US disclosed
US-4065430-A Functional group containing polymer and method of preparing the same FUJI PHOTO FILM CO., LTD. (JA) 1977-12-27 US disclosed
US-3933885-A Cinnamylideneacetic acid esters FUJI PHOTO FILM CO., LTD. (JA) 1976-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120035257-A1 Histone Deacetylase Inhibitors HDAC1, HDAC11, HDAC9 HDAC3 6/4885HDAC4 15/4885HDAC1 1/4885
US-20020099089-A1 Carboxylic acid amides, pharmaceutical compositions containing these compounds, their use and preparation TERT, NAT1, POT1 HDAC3 789/4885HDAC4 618/4885HDAC1 426/4885
US-20110288168-A1 HISTONE DEACETYLASE INHIBITORS HDAC1, HDAC6, HDAC5 HDAC3 6/4885HDAC4 10/4885HDAC1 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.