Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NCF1 | P14598 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.44 |
| ▸ | NOS1 | P29475 | 2/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27594166 | 0.81 | HPGD (0.51) | SMN1; SMN2RAB9ANPC1TP53TSHR | |
| SCHEMBL27705943 | 0.80 | CYP2C9 (0.46) | SMN1; SMN2RAB9ANPC1TP53TSHR | |
| SCHEMBL25137036 | 0.79 | HRH3 (0.62) | SMN1; SMN2RAB9ANPC1TP53TSHR | |
| SCHEMBL30059176 | 0.78 | HRH3 (0.59) | SMN1; SMN2RAB9ANPC1TP53TSHR | |
| SCHEMBL546487 | 0.78 | HRH3 (0.59) | SMN1; SMN2RAB9ANPC1TP53TSHR | |
| SCHEMBL4779922 | 0.77 | HRH3 (0.54) | SMN1; SMN2RAB9ANPC1TP53TSHR | |
| Ammonia Solution, Strong SCHEMBL548075 | 0.76 | HRH3 (0.58) | SMN1; SMN2RAB9ANPC1TP53TSHR | |
| SCHEMBL14615359 | 0.76 | HRH3 (0.50) | SMN1; SMN2RAB9ANPC1TP53TSHR | |
| SCHEMBL83489 | 0.76 | SKP2 (0.61) | SMN1; SMN2RAB9ANPC1HPGDHTT | |
| SCHEMBL27728431 | 0.74 | MAPK14 (0.45) | SMN1; SMN2RAB9ANPC1TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128461-B | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI | 2010-12-22 | — | — | CN | disclosed |
| CN-101128461-A | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI (US) | 2008-02-20 | — | — | CN | disclosed |