Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL1 | P55085 | 2/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 8/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HMGCR | P04035 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22001870 | 1.00 | F2RL1 (0.40) | F2RL1NFE2L2HRH4AMY1ARELA | |
| SCHEMBL27563320 | 0.83 | AMY1A (0.38) | NFE2L2AMY1ARELAFFAR1FFAR4 | |
| SCHEMBL10245246 | 0.79 | ESR1 (0.36) | NFE2L2AMY1ARELAFFAR1FFAR4 | |
| SCHEMBL876257 | 0.79 | NFE2L2 (0.39) | NFE2L2AMY1ARELAPKM | |
| SCHEMBL15093161 | 0.79 | NFE2L2 (0.39) | NFE2L2AMY1ARELAPKM | |
| SCHEMBL16951286 | 0.78 | NFE2L2 (0.61) | F2RL1NFE2L2HRH4PTGS1PTGS2 | |
| SCHEMBL14541331 | 0.78 | NFE2L2 (0.61) | F2RL1NFE2L2HRH4PTGS1PTGS2 | |
| SCHEMBL16308833 | 0.77 | ALOX5 (0.35) | BACE1HMGCRCYP3A4PTGS1PTGS2 | |
| SCHEMBL15792855 | 0.77 | ALOX5 (0.35) | BACE1HMGCRCYP3A4PTGS1PTGS2 | |
| SCHEMBL19337428 | 0.77 | F2RL1 (0.41) | F2RL1NFE2L2HRH4FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101048414-B | Fused tricyclic derivatives for the treatment of psychotic disorders | GLAXO GROUP LTD | 2011-09-07 | — | — | CN | disclosed |
| CN-101048414-A | Fused tricyclic derivatives for the treatment of psychotic disorders | GLAXO GROUP LTD (GB) | 2007-10-03 | — | — | CN | disclosed |