Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | TYMP | P19971 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8437240 | 0.73 | ALDH1A1 (0.41) | MAPK1ALDH1A1MAPTLMNAHTT | |
| SCHEMBL22299324 | 0.71 | ALDH1A1 (0.39) | MAPK1ALDH1A1MAPTLMNAHTT | |
| SCHEMBL2984229 | 0.67 | MAPT (0.42) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL12912881 | 0.64 | ALDH1A1 (0.37) | MAPK1ALDH1A1MAPTLMNAHTT | |
| SCHEMBL13319607 | 0.64 | ALDH1A1 (0.50) | MAPK1ALDH1A1MAPTLMNAHTT | |
| SCHEMBL8973903 | 0.62 | ALDH1A1 (0.55) | MAPK1ALDH1A1MAPTLMNAHTT | |
| SCHEMBL9489536 | 0.61 | NPC1 (0.47) | MAPK1ALDH1A1MAPTCYP2A6CYP2B6 | |
| SCHEMBL10568574 | 0.61 | PTGS1 (0.49) | MAPK1ALDH1A1MAPTLMNAHTT | |
| Biphenyl SCHEMBL664141 | 0.61 | ALDH1A1 (0.60) | MAPK1ALDH1A1MAPTLMNAHTT | |
| SCHEMBL2168449 | 0.61 | ALDH1A1 (0.50) | MAPK1ALDH1A1MAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101115749-B | Aminopyrimidine compounds and methods of use | AMGEN INC | 2011-06-22 | — | — | CN | disclosed |
| CN-101115749-A | Aminopyrimidine compounds and methods of use | AMGEN INC (US) | 2008-01-30 | — | — | CN | disclosed |