Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 8-Hydroxy Quinaldine SCHEMBL29024471 | 0.76 | METAP2 (0.79) | METAP2KMT2ACCR1RAB9ACCR5 | |
| SCHEMBL1029075 | 0.72 | MAPT (0.59) | METAP2KMT2ACCR1RAB9ACCR5 | |
| 2-Phenylphenol SCHEMBL7203851 | 0.72 | METAP2 (0.72) | METAP2KMT2ACCR1RAB9ACCR5 | |
| 2-Phenylphenol SCHEMBL2439345 | 0.71 | METAP2 (0.70) | METAP2KMT2ACCR1RAB9ACCR5 | |
| 8-Hydroxy Quinaldine SCHEMBL4564944 | 0.71 | METAP2 (0.70) | METAP2KMT2ACCR1RAB9ACCR5 | |
| 2-Phenylphenol SCHEMBL6759033 | 0.71 | METAP2 (0.70) | METAP2KMT2ACCR1RAB9ACCR5 | |
| 8-Hydroxy Quinaldine SCHEMBL29483489 | 0.70 | METAP2 (1.00) | METAP2KMT2ACCR1RAB9ACCR5 | |
| 8-Hydroxy Quinaldine SCHEMBL297247 | 0.70 | METAP2 (1.00) | METAP2KMT2ACCR1RAB9ACCR5 | |
| 8-Hydroxy Quinaldine SCHEMBL2436866 | 0.70 | METAP2 (0.68) | METAP2KMT2ACCR1RAB9ACCR5 | |
| SCHEMBL4226711 | 0.69 | ALDH1A1 (0.56) | KMT2ARAB9AMAPTMEN1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101223162-A | Indolylmaleimide derivatives | NOVARTIS AG (CH) | 2008-07-16 | — | — | CN | disclosed |