Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.54 |
| ▸ | METTL3 | Q86U44 | 4/20 | 0.40 |
| ▸ | METTL14 | Q9HCE5 | 4/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 3/20 | 0.37 |
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | BCL2 | P10415 | 3/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2771809 | 0.93 | NR1H4 (0.54) | NR1H4MAPK14PPARGPPARABCL2 | |
| SCHEMBL2773708 | 0.92 | NR1H4 (0.53) | NR1H4MAPK14PPARGPPARAPPARD | |
| SCHEMBL2772157 | 0.92 | NR1H4 (0.53) | NR1H4METTL3METTL14MAPK14PPARG | |
| SCHEMBL2786965 | 0.92 | NR1H4 (0.52) | NR1H4MAPK14PPARGPPARAPPARD | |
| SCHEMBL2772849 | 0.91 | NR1H4 (0.54) | NR1H4MAPK14PPARGPPARAMCL1 | |
| SCHEMBL2772480 | 0.88 | NR1H4 (0.60) | NR1H4PPARGPPARAMRGPRX4 | |
| SCHEMBL2770890 | 0.87 | NR1H4 (0.64) | NR1H4PPARGPPARAMRGPRX4 | |
| SCHEMBL2813670 | 0.87 | NR1H4 (0.57) | NR1H4MAPK14PPARGMRGPRX4 | |
| SCHEMBL2787707 | 0.86 | NR1H4 (0.59) | NR1H4PPARDMRGPRX4 | |
| SCHEMBL2771269 | 0.84 | NR1H4 (0.56) | NR1H4PPARDFFAR1MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |