Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | PYGL | P06737 | 12/20 | 0.54 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | F7 | P08709 | 1/20 | 0.49 |
| ▸ | F3 | P13726 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27709042 | 0.91 | ALOX15 (0.60) | HRH4HRH3PYGL | |
| SCHEMBL6350243 | 0.79 | PYGL (0.62) | HRH4HRH3PYGLNHERF1F7 | |
| SCHEMBL5869858 | 0.77 | PYGL (0.56) | HRH4HRH3PYGLNHERF1 | |
| SCHEMBL5869825 | 0.77 | PYGL (0.56) | HRH4HRH3PYGLNHERF1 | |
| SCHEMBL5869836 | 0.77 | PYGL (0.56) | HRH4HRH3PYGLNHERF1 | |
| SCHEMBL27709050 | 0.76 | MEN1 (0.48) | — | |
| SCHEMBL27729464 | 0.76 | OPRM1 (0.49) | — | |
| SCHEMBL13753365 | 0.76 | ALOX15 (0.79) | HRH4HRH3PYGLNHERF1CNR1 | |
| SCHEMBL2410978 | 0.76 | HDAC3 (0.56) | HRH4HRH3PYGLNHERF1CNR1 | |
| SCHEMBL28757959 | 0.75 | PYGL (0.50) | HRH4HRH3PYGLNHERF1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101208334-B | Novel cyclic amines | HOFFMANN LA ROCHE | 2012-06-13 | — | — | CN | disclosed |
| CN-101208334-A | Novel cyclic amines | HOFFMANN LA ROCHE (CH) | 2008-06-25 | — | — | CN | disclosed |