Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 2/20 | 0.36 |
| ▸ | BDKRB2 | P30411 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 2/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1860622 | 1.00 | METAP2 (0.38) | METAP2RENBDKRB2ALDH1A1KMT2A | |
| SCHEMBL1863823 | 0.97 | METAP2 (0.39) | METAP2RENBDKRB2ALDH1A1KMT2A | |
| SCHEMBL1862541 | 0.93 | METAP2 (0.34) | METAP2RENGPR88CTSKCTSL | |
| SCHEMBL3612224 | 0.89 | GPR88 (0.34) | METAP2RENGPR88CTSK | |
| SCHEMBL1868000 | 0.89 | GPR88 (0.34) | METAP2RENGPR88CTSK | |
| SCHEMBL1864029 | 0.88 | GPR88 (0.32) | METAP2RENGPR88CTSKCTSL | |
| SCHEMBL1864027 | 0.88 | GPR88 (0.32) | METAP2RENGPR88CTSKCTSL | |
| SCHEMBL1867741 | 0.88 | CTSK (0.33) | METAP2RENGPR88CTSKCTSL | |
| SCHEMBL1863146 | 0.85 | CTSK (0.34) | METAP2RENGPR88CTSKCTSL | |
| SCHEMBL1863912 | 0.84 | GPR88 (0.33) | METAP2GPR88CTSKCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101072561-B | Diaminoalkane aspartic protease inhibitors | VITAE PHARMACEUTICALS INC | 2011-05-11 | — | — | CN | disclosed |
| CN-101072561-A | Diaminoalkane aspartic protease inhibitors | VITAE PHARMACEUTICALS INC (US) | 2007-11-14 | — | — | CN | disclosed |