Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | IDE | P14735 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807270 | 0.85 | LMNA (0.47) | LMNAPTGS2ALDH1A1MAPTPDK1 | |
| SCHEMBL27709890 | 0.83 | PTGDR2 (0.39) | ALDH1A1MAPT | |
| SCHEMBL27690016 | 0.80 | AKR1C3 (0.38) | LMNAPTGS2ALDH1A1AKR1C3AKR1C2 | |
| SCHEMBL13055320 | 0.79 | LMNA (0.42) | LMNAPTGS2ALDH1A1MAPTGLA | |
| SCHEMBL28766217 | 0.75 | KIF11 (0.45) | PTGS2LRRK2PTGS1 | |
| SCHEMBL755309 | 0.74 | LMNA (0.60) | LMNAPTGS2ALDH1A1MAPTGLA | |
| SCHEMBL9988774 | 0.73 | LMNA (0.50) | LMNAPTGS2ALDH1A1MAPTPDK1 | |
| SCHEMBL30526834 | 0.73 | LMNA (0.50) | LMNAPTGS2ALDH1A1MAPTPDK1 | |
| SCHEMBL399056 | 0.73 | LMNA (0.46) | LMNAPTGS2ALDH1A1MAPTPDK1 | |
| SCHEMBL7626733 | 0.73 | KMT2A (0.46) | LMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103384672-A | N-substituted oxazinopteridines and oxazinopteridinones | TAKAEDA CHEMICAL IND LTD | 2013-11-06 | — | — | CN | disclosed |
| CN-101553483-B | 2-(piperidin-4-yl)-4-phenoxy-or phenylamino-pyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors | HOFFMANN LA ROCHE | 2013-04-17 | — | — | CN | disclosed |
| CN-102869660-A | Aminothiazolones as estrogen related receptor-alpha modulators | JANSSEN PHARMACEUTICA NV | 2013-01-09 | — | — | CN | disclosed |
| CN-101035786-B | Pyrrolopyridine derivatives and their use as CRTH2 antagonists | NOVARTIS AG | 2012-08-29 | — | — | CN | disclosed |
| CN-102603581-A | PYRROLO[2,3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON INC | 2012-07-25 | — | — | CN | disclosed |
| CN-101243084-B | Pyrrolo [2,3-B ] pyridine derivatives as protein kinase inhibitors | PLEXXIKON INC | 2012-03-07 | — | — | CN | disclosed |
| CN-102206216-A | Pyrrolo[2,3-B] pyridine derivatives as protein kinase inhibitors | PLEXXIKON INC | 2011-10-05 | — | — | CN | disclosed |
| CN-101553483-A | 2-(piperidin-4-yl)-4-phenoxy-or phenylamino-pyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors | HOFFMANN LA ROCHE (CH) | 2009-10-07 | — | — | CN | disclosed |
| CN-101309921-A | Use of pyrrolo[2,3-B]pyridines to prepare a medicament for treating pain | NOVARTIS AG (CH) | 2008-11-19 | — | — | CN | disclosed |
| CN-101243084-A | Pyrrolo [2, 3-B ] pyridine derivatives as protein kinase inhibitors | PLEXXIKON INC (US) | 2008-08-13 | — | — | CN | disclosed |
| CN-101035786-A | Pyrrolopyridine derivatives and their use as CRTH2 antagonists | NOVARTIS AG (CH) | 2007-09-12 | — | — | CN | disclosed |