Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27704996 | 0.84 | KEAP1 (0.58) | KEAP1NFE2L2PDK2BCAT2METAP2 | |
| SCHEMBL145431 | 0.83 | DGAT1 (0.46) | KEAP1NFE2L2BCAT2DGAT1METAP2 | |
| SCHEMBL27730957 | 0.81 | KDM4E (0.52) | KEAP1NFE2L2PDK2BCAT2PARP1 | |
| SCHEMBL27710545 | 0.79 | KEAP1 (0.49) | KEAP1NFE2L2PDK2BCAT2PARP1 | |
| SCHEMBL27710624 | 0.79 | KEAP1 (0.49) | KEAP1NFE2L2PDK2BCAT2METAP2 | |
| SCHEMBL27710628 | 0.79 | KEAP1 (0.49) | KEAP1NFE2L2PDK2BCAT2DGAT1 | |
| SCHEMBL1898663 | 0.79 | KEAP1 (0.56) | KEAP1NFE2L2PDK2BCAT2METAP2 | |
| SCHEMBL27710590 | 0.77 | DGAT1 (0.44) | KEAP1NFE2L2PDK2DGAT1METAP2 | |
| SCHEMBL27731031 | 0.77 | PARP1 (0.43) | KEAP1NFE2L2PDK2BCAT2DGAT1 | |
| SCHEMBL27725563 | 0.77 | KEAP1 (0.58) | KEAP1NFE2L2PDK2BCAT2METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101186586-A | N,N'-difluorophenyl derivative of 4-methoxyl-1,3-phthalamide and use thereof | UNIV TIANJIN TECHNOLOGY (CN) | 2008-05-28 | — | — | CN | claimed |
| CN-101186586-B | N,N'-difluorophenyl derivative of 4-methoxyl-1,3-phthalamide and use thereof | UNIV TIANJIN TECHNOLOGY | 2010-06-30 | — | — | CN | disclosed |
| CN-101186586-A | N,N'-difluorophenyl derivative of 4-methoxyl-1,3-phthalamide and use thereof | UNIV TIANJIN TECHNOLOGY (CN) | 2008-05-28 | — | — | CN | disclosed |