Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.36 |
| ▸ | MYLK | Q15746 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27731054 | 0.82 | PARP1 (0.44) | PARP1KEAP1NFE2L2LMNAPDK2 | |
| SCHEMBL27710617 | 0.81 | PARP1 (0.43) | PARP1KEAP1NFE2L2LMNAPDK2 | |
| SCHEMBL27710647 | 0.81 | PARP1 (0.43) | PARP1KEAP1NFE2L2LMNAPDK2 | |
| SCHEMBL27704996 | 0.78 | KEAP1 (0.58) | PARP1KEAP1NFE2L2PDK2ALDH1A1 | |
| SCHEMBL2523960 | 0.77 | DGAT1 (0.50) | PARP1KEAP1DGAT1LMNAALDH1A1 | |
| SCHEMBL27710601 | 0.77 | KEAP1 (0.49) | PARP1KEAP1NFE2L2DGAT1PDK2 | |
| SCHEMBL27710519 | 0.76 | TDP1 (0.46) | PARP1KEAP1NFE2L2LMNAALDH1A1 | |
| SCHEMBL27710707 | 0.74 | DGAT1 (0.57) | PARP1KEAP1NFE2L2DGAT1LMNA | |
| SCHEMBL27731009 | 0.74 | KIF11 (0.51) | PARP1KEAP1NFE2L2DGAT1PDK2 | |
| SCHEMBL30881641 | 0.74 | DGAT1 (0.41) | PARP1DGAT1MAPK14PRKD3MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101186586-A | N,N'-difluorophenyl derivative of 4-methoxyl-1,3-phthalamide and use thereof | UNIV TIANJIN TECHNOLOGY (CN) | 2008-05-28 | — | — | CN | claimed |
| CN-101186586-B | N,N'-difluorophenyl derivative of 4-methoxyl-1,3-phthalamide and use thereof | UNIV TIANJIN TECHNOLOGY | 2010-06-30 | — | — | CN | disclosed |
| CN-101186586-A | N,N'-difluorophenyl derivative of 4-methoxyl-1,3-phthalamide and use thereof | UNIV TIANJIN TECHNOLOGY (CN) | 2008-05-28 | — | — | CN | disclosed |