Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TSPO | P30536 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | GRM6 | O15303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5438598 | 0.75 | MAPK1 (0.56) | ALDH1A1MAPK1SMN1; SMN2TSPOKMT2A | |
| SCHEMBL5437513 | 0.74 | TSPO (0.61) | ALDH1A1MAPK1TSPOHPGDMEN1 | |
| SCHEMBL5183007 | 0.74 | NPC1 (0.47) | ALDH1A1TSHRSMN1; SMN2MAPTKDM4E | |
| SCHEMBL5435733 | 0.74 | ALDH1A1 (0.50) | ALDH1A1MAPK1SMN1; SMN2MAPTTSPO | |
| SCHEMBL5436962 | 0.74 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2MAPTHPGDKDM4E | |
| SCHEMBL5434352 | 0.72 | TSPO (0.52) | ALDH1A1MAPK1SMN1; SMN2MAPTTSPO | |
| SCHEMBL5440241 | 0.71 | MKNK1 (0.54) | ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL5437499 | 0.71 | PLA2G7 (0.54) | ALDH1A1MAPK1SMN1; SMN2TSPOKMT2A | |
| SCHEMBL5431656 | 0.69 | MAPT (0.55) | ALDH1A1TSHRMAPTMEN1KMT2A | |
| SCHEMBL5450905 | 0.69 | ALDH1A1 (0.55) | ALDH1A1MAPK1SMN1; SMN2MAPTTSPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101061098-B | Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors | JANSSEN PHARMACEUTICA NV | 2012-05-23 | — | — | CN | claimed |
| CN-101061098-B | Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors | JANSSEN PHARMACEUTICA NV | 2012-05-23 | — | — | CN | disclosed |
| CN-101061098-A | Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors | JANSSEN PHARMACEUTICA NV (BE) | 2007-10-24 | — | — | CN | disclosed |