Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.44 |
| ▸ | CTSA | P10619 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | VHL | P40337 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27691528 | 0.78 | EGLN2 (0.42) | EGLN2CYP11B1CYP11B2 | |
| SCHEMBL16675750 | 0.75 | CHEK1 (0.60) | CHEK1CTSAEGLN2CYP11B1CYP11B2 | |
| SCHEMBL453185 | 0.73 | CHEK1 (0.44) | CHEK1EGLN2CYP11B1CYP11B2GRM2 | |
| SCHEMBL27711670 | 0.72 | BACE1 (0.43) | — | |
| SCHEMBL27858794 | 0.71 | MAPT (0.50) | GRM2 | |
| SCHEMBL27711658 | 0.71 | CTSA (0.41) | CHEK1CTSAPDE10AEGLN2KCNH2 | |
| SCHEMBL3783612 | 0.70 | EGLN2 (0.44) | CHEK1CTSAPDE10AEGLN2VHL | |
| SCHEMBL12630708 | 0.69 | CHEK1 (0.51) | CHEK1CTSAPDE10AEGLN2CYP11B2 | |
| SCHEMBL4651566 | 0.69 | TSHR (0.44) | — | |
| SCHEMBL17116597 | 0.68 | DGAT1 (0.48) | CHEK1CTSAPDE10AEGLN2CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101061105-B | Potentiators of glutamate receptors | LILLY CO ELI | 2012-05-30 | — | — | CN | disclosed |
| CN-101061105-A | Potentiators of glutamate receptors | LILLY CO ELI (US) | 2007-10-24 | — | — | CN | disclosed |