Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | PRF1 | P14222 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27691528 | 0.86 | EGLN2 (0.42) | MMP12MMP13HSD17B1HSD17B2 | |
| SCHEMBL4651566 | 0.80 | TSHR (0.44) | BACE1HPGDSHSD17B1HSD17B2ADORA3 | |
| SCHEMBL688074 | 0.77 | PRKCI (0.53) | CLK4MMP12MMP13PTPN5XDH | |
| SCHEMBL7660410 | 0.76 | MMP12 (0.55) | CLK4MMP12MMP13PTPN5XDH | |
| SCHEMBL29742824 | 0.75 | SLC22A12 (0.50) | BACE1CLK4MMP12MMP13PTPN5 | |
| SCHEMBL28645733 | 0.75 | SLC22A12 (0.50) | BACE1CLK4MMP12MMP13PTPN5 | |
| SCHEMBL29478750 | 0.73 | GLA (0.50) | NOTUMENPP2 | |
| SCHEMBL92972 | 0.73 | GLA (0.50) | NOTUMENPP2 | |
| SCHEMBL27711665 | 0.72 | CHEK1 (0.44) | — | |
| SCHEMBL8105479 | 0.71 | PRF1 (0.60) | BACE1CLK4PTPN5XDHSLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101061105-B | Potentiators of glutamate receptors | LILLY CO ELI | 2012-05-30 | — | — | CN | disclosed |
| CN-101061105-A | Potentiators of glutamate receptors | LILLY CO ELI (US) | 2007-10-24 | — | — | CN | disclosed |