Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | VHL | P40337 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27691521 | 0.76 | PTGS1 (0.55) | EGLN2CYP2A6PTGS1 | |
| SCHEMBL27858798 | 0.71 | MAPT (0.45) | CTSACYP2C19PDE10AGRM2 | |
| SCHEMBL27711665 | 0.71 | CHEK1 (0.44) | CTSACHEK1EGLN2KCNH2PDE10A | |
| SCHEMBL12630708 | 0.69 | CHEK1 (0.51) | CTSACHEK1EGLN2PDE10AGRIN2B | |
| SCHEMBL27691534 | 0.69 | CLK4 (0.41) | CYP3A4CYP2C19PTGS1 | |
| SCHEMBL4963879 | 0.67 | TP53 (0.39) | PTGS1 | |
| SCHEMBL31661869 | 0.67 | BCAT2 (0.53) | CTSACHEK1EGLN2PDE10APTGS1 | |
| SCHEMBL453185 | 0.67 | CHEK1 (0.44) | CHEK1EGLN2GRM2 | |
| SCHEMBL5111011 | 0.67 | TP53 (0.57) | CYP2A6PTGS1 | |
| SCHEMBL3783612 | 0.67 | EGLN2 (0.44) | CTSACHEK1EGLN2PDE10AVHL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101061105-B | Potentiators of glutamate receptors | LILLY CO ELI | 2012-05-30 | — | — | CN | disclosed |
| CN-101061105-A | Potentiators of glutamate receptors | LILLY CO ELI (US) | 2007-10-24 | — | — | CN | disclosed |