Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1249258 | 0.80 | ALDH1A1 (0.53) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL6667841 | 0.78 | ALDH1A1 (0.46) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL903306 | 0.78 | ALDH1A1 (0.50) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL4667159 | 0.76 | SMN1; SMN2 (0.39) | ALDH1A1KMT2A | |
| SCHEMBL901093 | 0.74 | ALDH1A1 (0.46) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| Acetic Acid SCHEMBL28254246 | 0.73 | ALDH1A1 (0.50) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL27730937 | 0.71 | MGAM (0.46) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL14139334 | 0.71 | ALOX15 (0.52) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| Acetic Acid SCHEMBL1660055 | 0.71 | ALDH1A1 (0.48) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| Acetic Acid SCHEMBL4138880 | 0.71 | ALDH1A1 (0.48) | ALDH1A1LMNAHSD17B10ALOX15MGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1949893-B1 | Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors | SHIRE BIOPHARMACEUTICALS HOLDI (GB) | 2010-10-13 | — | — | EP | disclosed |
| US-7700608-B2 | Quinazoline derivatives and their use in the treatment of thrombocythemia | SHIRE HOLDINGS AG (CH) | 2010-04-20 | — | — | US | disclosed |
| US-20100093772-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF THROMBOCYTHEMIA | SHIRE HOLDINGS AG (CH) | 2010-04-15 | — | — | US | disclosed |
| EP-1781296-B1 | QUINAZOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF THROMBOCYTHEMIA | SHIRE HOLDINGS AG (CH) | 2010-03-10 | — | — | EP | disclosed |
| EP-1781296-A4 | QUINAZOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF THROMBOCYTHEMIA | SHIRE HOLDINGS AG (CH) | 2008-08-20 | — | — | EP | disclosed |
| EP-1778235-A4 | QUINAZOLINE DERIVATIVES USEFUL FOR THE TREATMENT OF PERIPHERAL ARTERIAL DISEASE AND AS PHOSPHODIESTERASE INHIBITORS | SHIRE HOLDINGS AG (CH) | 2008-08-20 | — | — | EP | disclosed |
| EP-1949893-A2 | Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors | Shire Holdings AG (CH) | 2008-07-30 | — | — | EP | disclosed |
| EP-1781296-A2 | QUINAZOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF THROMBOCYTHEMIA | Shire Holdings AG (CH) | 2007-05-09 | — | — | EP | disclosed |
| EP-1778235-A2 | QUINAZOLINE DERIVATIVES USEFUL FOR THE TREATMENT OF PERIPHERAL ARTERIAL DISEASE AND AS PHOSPHODIESTERASE INHIBITORS | Shire Holdings AG (CH) | 2007-05-02 | — | — | EP | disclosed |
| US-20060052601-A1 | Quinazoline derivatives and their use in the treatment of thrombocythemia | SHIRE HOLDINGS AG (CH) | 2006-03-09 | — | — | US | disclosed |
| WO-2006017822-A2 | QUINAZOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF THROMBOCYTHEMIA | SHIRE HOLDINGS AG (CH) | 2006-02-16 | — | — | WO | disclosed |
| WO-2006017823-A2 | QUINAZOLINE DERIVATIVES USEFUL FOR THE TREATMENT OF PERIPHERAL ARTERIAL DISEASE AND AS PHOSPHODIESTERASE INHIBITORS | SHIRE HOLDINGS AG (CH) | 2006-02-16 | — | — | WO | disclosed |
| US-20060030574-A1 | Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors | SHIRE HOLDINGS AG (CH) | 2006-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052601-A1 | Quinazoline derivatives and their use in the treatment of thrombocythemia | ABL1, MPL, PFKP | ALDH1A1 1401/4885LMNA 2769/4885HSD17B10 3698/4885 |
| US-20100093772-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF THROMBOCYTHEMIA | ABL1, MPL, PFKP | ALDH1A1 1401/4885LMNA 2769/4885HSD17B10 3698/4885 |
| US-20060030574-A1 | Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors | PDE3B, PDE3A, PDE5A | ALDH1A1 952/4885LMNA 2603/4885HSD17B10 921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.