Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | LDHA | P00338 | 1/20 | 0.47 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.44 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27868946 | 0.80 | CES2 (0.53) | LDHAEPHX1PKMFFAR1 | |
| SCHEMBL10519643 | 0.79 | ALDH1A1 (0.52) | IDO1PKMFFAR1 | |
| SCHEMBL5028690 | 0.78 | IDO1 (0.62) | IDO1SMN1; SMN2HTTLDHAF2RL1 | |
| SCHEMBL190895 | 0.77 | IDO1 (0.55) | IDO1SMN1; SMN2APP | |
| SCHEMBL5637946 | 0.76 | MTNR1A (0.53) | SMN1; SMN2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7334996 | 0.75 | GAA (0.57) | IDO1SMN1; SMN2HTTLDHAPKM | |
| Hydrochloric Acid SCHEMBL5797808 | 0.75 | IDO1 (0.56) | IDO1SMN1; SMN2APP | |
| SCHEMBL8488722 | 0.74 | IDO1 (0.62) | IDO1SMN1; SMN2HTTLDHAF2RL1 | |
| SCHEMBL9861753 | 0.74 | BCHE (0.49) | IDO1SMN1; SMN2HTTLDHAEPHX1 | |
| SCHEMBL6571602 | 0.73 | IDO1 (0.67) | IDO1SMN1; SMN2HTTAPPHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101248043-A | Novel 2-azetidinone derivatives as cholesterol absorption inhibitors useful for the treatment of hyperlipidaemic conditions | ASTRAZENECA AB (SE) | 2008-08-20 | — | — | CN | disclosed |
| CN-101243044-A | Novel 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions | ASTRAZENECA AB (SE) | 2008-08-13 | — | — | CN | disclosed |
| CN-101243076-A | 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions | ASTRAZENECA AB (SE) | 2008-08-13 | — | — | CN | disclosed |