Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | CA4 | P22748 | 5/20 | 0.48 |
| ▸ | CA1 | P00915 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | CA7 | P43166 | 3/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA6 | P23280 | 2/20 | 0.48 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.48 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | DBH | P09172 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL9935253 | 0.90 | SMN1; SMN2 (0.44) | CA2KDM4ECA4CA1ALDH1A1 | |
| SCHEMBL15059320 | 0.89 | — | — | |
| SCHEMBL49313 | 0.89 | — | — | |
| SCHEMBL29573828 | 0.89 | — | — | |
| SCHEMBL3440828 | 0.89 | ALDH1A1 (0.56) | CA2KDM4ECA4CA1ALDH1A1 | |
| Urea SCHEMBL8365790 | 0.87 | KDM4E (0.50) | CA2KDM4ECA4CA1ALDH1A1 | |
| Acetone SCHEMBL27732461 | 0.87 | THRB (0.46) | CA2KDM4ECA4CA1ALDH1A1 | |
| Formaldehyde SCHEMBL674875 | 0.86 | ALDH1A1 (0.47) | CA2KDM4ECA4CA1ALDH1A1 | |
| Benzoic Acid SCHEMBL28516539 | 0.86 | NAPRT (0.61) | CA2KDM4ECA4CA1ALDH1A1 | |
| Fumaric Acid SCHEMBL8377318 | 0.86 | CA1 (0.53) | CA2KDM4ECA4CA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101094593-B | Antimicrobial and antiviral product | APPEARTEX AB | 2013-10-16 | — | — | CN | disclosed |
| CN-101094593-A | Antimicrobial and antiviral product | APPEARTEX AB (SE) | 2007-12-26 | — | — | CN | disclosed |