Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.36 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28768848 | 0.89 | MAPT (0.39) | MAPTLMNASMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL28769034 | 0.89 | MAPT (0.39) | MAPTLMNASMN1; SMN2TP53AOC3 | |
| SCHEMBL27714640 | 0.89 | MAPT (0.43) | MAPTMAPK14LMNASMN1; SMN2TP53 | |
| SCHEMBL5218842 | 0.87 | MAPT (0.48) | MAPTMAPK14LMNASMN1; SMN2TP53 | |
| SCHEMBL27714654 | 0.85 | AVPR1B (0.38) | MAPTLMNASMN1; SMN2TP53AOC3 | |
| SCHEMBL5219268 | 0.83 | BLM (0.49) | MAPTLMNASMN1; SMN2CACNA1GCACNA1H | |
| SCHEMBL27714648 | 0.82 | FNTA (0.40) | MAPTLMNASMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL5215826 | 0.82 | MAPT (0.47) | MAPTLMNASMN1; SMN2TP53RAB9A | |
| SCHEMBL5219606 | 0.82 | MAPT (0.44) | MAPTLMNASMN1; SMN2TP53RAB9A | |
| Cyclopropane SCHEMBL27714655 | 0.81 | AOC3 (0.43) | MAPTLMNASMN1; SMN2TP53AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101115528-A | Inhibitors of HIV-1 capsid formation: substituted aryl aminomethyl thiazole ureas and analogs thereof | ACHILLION PHARMACEUTICALS INC (US) | 2008-01-30 | — | — | CN | claimed |
| CN-101115528-A | Inhibitors of HIV-1 capsid formation: substituted aryl aminomethyl thiazole ureas and analogs thereof | ACHILLION PHARMACEUTICALS INC (US) | 2008-01-30 | — | — | CN | disclosed |