Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.36 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | WRN | Q14191 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27714643 | 0.89 | MAPT (0.43) | MAPTLMNASMN1; SMN2TP53RAB9A | |
| SCHEMBL27714640 | 0.89 | MAPT (0.43) | MAPTLMNASMN1; SMN2TP53RAB9A | |
| SCHEMBL28769034 | 0.89 | MAPT (0.39) | MAPTLMNASMN1; SMN2TP53RAB9A | |
| SCHEMBL5215570 | 0.87 | MAPT (0.43) | MAPTLMNASMN1; SMN2TP53RAB9A | |
| SCHEMBL27714654 | 0.85 | AVPR1B (0.38) | MAPTLMNASMN1; SMN2TP53RAB9A | |
| SCHEMBL27714648 | 0.82 | FNTA (0.40) | MAPTLMNASMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL5219298 | 0.82 | MAPT (0.50) | MAPTLMNASMN1; SMN2TP53RAB9A | |
| SCHEMBL5215826 | 0.82 | MAPT (0.47) | MAPTLMNASMN1; SMN2TP53RAB9A | |
| SCHEMBL5219606 | 0.82 | MAPT (0.44) | MAPTLMNASMN1; SMN2TP53RAB9A | |
| Cyclopropane SCHEMBL27714655 | 0.81 | AOC3 (0.43) | MAPTLMNASMN1; SMN2TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101115528-A | Inhibitors of HIV-1 capsid formation: substituted aryl aminomethyl thiazole ureas and analogs thereof | ACHILLION PHARMACEUTICALS INC (US) | 2008-01-30 | — | — | CN | claimed |
| CN-101115528-A | Inhibitors of HIV-1 capsid formation: substituted aryl aminomethyl thiazole ureas and analogs thereof | ACHILLION PHARMACEUTICALS INC (US) | 2008-01-30 | — | — | CN | disclosed |