Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27805644 | 0.85 | SMN1; SMN2 (0.47) | HRH3HPGDSMN1; SMN2TSHRKMT2A | |
| SCHEMBL522487 | 0.84 | HRH3 (0.70) | HRH3HPGDSMN1; SMN2USP2TSHR | |
| SCHEMBL1014002 | 0.81 | HPGD (0.86) | HRH3HPGDSMN1; SMN2USP2TSHR | |
| SCHEMBL28784126 | 0.81 | HRH3 (0.46) | HRH3HPGDSMN1; SMN2TSHRKMT2A | |
| SCHEMBL13636330 | 0.80 | HRH3 (1.00) | HRH3HPGDSMN1; SMN2USP2TSHR | |
| Hydrochloric Acid SCHEMBL1177194 | 0.79 | HRH3 (0.97) | HRH3HPGDSMN1; SMN2USP2TSHR | |
| SCHEMBL10184001 | 0.79 | HRH3 (0.78) | HRH3HPGDSMN1; SMN2USP2TSHR | |
| SCHEMBL1450838 | 0.79 | HRH3 (0.78) | HRH3HPGDSMN1; SMN2USP2TSHR | |
| SCHEMBL3456205 | 0.78 | HPGD (1.00) | HRH3HPGDSMN1; SMN2USP2TSHR | |
| SCHEMBL27939943 | 0.78 | ALDH1A1 (0.57) | HPGDSMN1; SMN2GAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102659718-B | Prepare the method for cyclopropyl-amide derivatives | JANSSEN PHARMACEUTICA N. V. (BE) | 2015-11-25 | — | — | CN | disclosed |
| CN-101321730-B | Cyclopropylamines as modulators of the histamine H3 receptor | JANSSEN PHARMACEUTICA NV | 2012-11-14 | — | — | CN | disclosed |
| CN-102659718-A | Processes for the preparation of cyclopropyl-amide derivatives | JANSSEN PHARMACEUTICA NV | 2012-09-12 | — | — | CN | disclosed |
| CN-101300242-B | Process for preparing cyclopropyl-amide derivatives | JANSSEN PHARMACEUTICA NV | 2012-07-11 | — | — | CN | disclosed |
| CN-101389617-A | Novel processes for the preparation of piperazinyl and diazapanyl benzamide derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2009-03-18 | — | — | CN | disclosed |
| CN-101321730-A | Cyclopropylamines as modulators of the histamine H3 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2008-12-10 | — | — | CN | disclosed |
| CN-101300242-A | Process for preparing cyclopropyl-amide derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2008-11-05 | — | — | CN | disclosed |