Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 9/20 | 0.51 |
| ▸ | BRAF | P15056 | 8/20 | 0.49 |
| ▸ | ARAF | P10398 | 3/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.49 |
| ▸ | FLT1 | P17948 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27720157 | 0.87 | MAPT (0.64) | RAF1BRAFARAFEPHX2MEN1 | |
| SCHEMBL27720100 | 0.86 | BRAF (0.63) | RAF1BRAFARAFEPHX2MEN1 | |
| SCHEMBL27720112 | 0.85 | EPHX2 (0.50) | RAF1BRAFARAFEPHX2MEN1 | |
| SCHEMBL27740980 | 0.84 | MAPK14 (0.56) | RAF1EPHX2ABL1KDRMAPK14 | |
| SCHEMBL27740982 | 0.84 | KDR (0.53) | RAF1BRAFEPHX2KDRMAPK14 | |
| SCHEMBL27720191 | 0.83 | CDK8 (0.55) | RAF1BRAFMEN1KMT2AABL1 | |
| SCHEMBL27720155 | 0.82 | BRAF (0.64) | RAF1BRAFARAFEPHX2ABL1 | |
| SCHEMBL27720117 | 0.81 | BRAF (0.61) | RAF1BRAFARAFEPHX2MEN1 | |
| SCHEMBL27720129 | 0.81 | MEN1 (0.66) | RAF1BRAFARAFEPHX2MEN1 | |
| SCHEMBL27740983 | 0.80 | CDK8 (0.56) | RAF1BRAFMEN1KMT2AABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101298427-B | Diaryl urea compound and use thereof | GUANGZHOU INST BIOMED & HEALTH | 2012-03-21 | — | — | CN | disclosed |
| CN-101298427-A | Diaryl urea compound and use thereof | GUANGZHOU INST BIOMED & HEALTH (CN) | 2008-11-05 | — | — | CN | disclosed |