Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 9/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.64 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.51 |
| ▸ | RAF1 | P04049 | 3/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | ARAF | P10398 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27720117 | 0.91 | BRAF (0.61) | BRAFHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL27720100 | 0.91 | BRAF (0.63) | BRAFHDAC1S1PR2HDAC3HDAC4 | |
| SCHEMBL27740983 | 0.89 | CDK8 (0.56) | BRAFHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL27720157 | 0.88 | MAPT (0.64) | BRAFHDAC1S1PR2HDAC3HDAC4 | |
| SCHEMBL27720144 | 0.87 | TP53 (0.62) | BRAFHDAC1RAF1ARAFNPC1 | |
| SCHEMBL27720178 | 0.87 | RAB9A (0.60) | BRAFHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL27720191 | 0.86 | CDK8 (0.55) | BRAFHDAC1RAF1NPC1RAB9A | |
| SCHEMBL27720107 | 0.85 | MEN1 (0.61) | BRAFHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL27720129 | 0.84 | MEN1 (0.66) | BRAFHDAC1S1PR2HDAC3HDAC4 | |
| SCHEMBL27720160 | 0.80 | BRAF (0.60) | BRAFHDAC1HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101298427-B | Diaryl urea compound and use thereof | GUANGZHOU INST BIOMED & HEALTH | 2012-03-21 | — | — | CN | disclosed |
| CN-101298427-A | Diaryl urea compound and use thereof | GUANGZHOU INST BIOMED & HEALTH (CN) | 2008-11-05 | — | — | CN | disclosed |