Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.56 |
| ▸ | SRC | P12931 | 5/20 | 0.56 |
| ▸ | KDR | P35968 | 4/20 | 0.53 |
| ▸ | ABL1 | P00519 | 6/20 | 0.53 |
| ▸ | MET | P08581 | 2/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27720112 | 0.92 | EPHX2 (0.50) | MAPK14SRCKDRABL1MET | |
| SCHEMBL27740982 | 0.91 | KDR (0.53) | MAPK14SRCKDREPHX2RAF1 | |
| SCHEMBL27720106 | 0.84 | RAF1 (0.51) | MAPK14SRCKDRABL1MET | |
| SCHEMBL27720109 | 0.84 | MAPK14 (0.52) | MAPK14SRCKDRMETEPHX2 | |
| SCHEMBL27720139 | 0.84 | ALDH1A1 (0.52) | MAPK14SRCKDRABL1MET | |
| SCHEMBL27720161 | 0.83 | HTR2A (0.51) | MAPK14SRCKDRMETEPHX2 | |
| SCHEMBL27740975 | 0.81 | RAB9A (0.50) | MAPK14SRCKDRABL1MET | |
| SCHEMBL27720157 | 0.80 | MAPT (0.64) | MAPK14SRCKDRABL1MET | |
| SCHEMBL27720100 | 0.79 | BRAF (0.63) | MAPK14SRCKDRABL1MET | |
| SCHEMBL27740984 | 0.78 | S1PR1 (0.51) | MAPK14SRCKDRABL1MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101298427-B | Diaryl urea compound and use thereof | GUANGZHOU INST BIOMED & HEALTH | 2012-03-21 | — | — | CN | disclosed |
| CN-101298427-A | Diaryl urea compound and use thereof | GUANGZHOU INST BIOMED & HEALTH (CN) | 2008-11-05 | — | — | CN | disclosed |