Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.56 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL171415 | 0.89 | SMN1; SMN2 (0.73) | IDO1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL14384396 | 0.84 | MTNR1A (0.76) | IDO1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL9571811 | 0.84 | MTNR1A (0.71) | IDO1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL13728829 | 0.81 | IDO1 (0.71) | IDO1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL6814406 | 0.81 | CYP1A2 (0.69) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL3468387 | 0.81 | MAPT (0.68) | IDO1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL11481934 | 0.81 | IDO1 (0.66) | IDO1NPC1RAB9ASMN1; SMN2MEN1 | |
| Nitric Acid SCHEMBL5354098 | 0.80 | ALDH1A1 (0.52) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL10923463 | 0.80 | IDO1 (0.57) | IDO1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL18409069 | 0.79 | NPC1 (0.67) | IDO1NPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101309917-B | Stomach H with enhanced therapeutic properties+，K+-deuteration inhibitors of ATPase | AUSPEX PHARMACEUTICALS INC | 2013-09-11 | — | — | CN | disclosed |
| CN-101309917-A | Stomach H with enhanced therapeutic properties+，K+-deuteration inhibitors of ATPase | AUSPEX PHARMACEUTICALS INC (US) | 2008-11-19 | — | — | CN | disclosed |