Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 7/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28244805 | 0.77 | — | — | |
| SCHEMBL7522724 | 0.76 | HTR2A (0.38) | HTR2AHTR2CCHRM1 | |
| SCHEMBL27277657 | 0.76 | HTR2A (0.41) | HTR2AHTR2CHTR2BTAAR1HRH3 | |
| SCHEMBL27959108 | 0.74 | HTR2A (0.41) | HTR2AHTR2CCHRM1 | |
| SCHEMBL3462 | 0.73 | HTR2A (0.42) | HTR2AHTR2CHTR2BTAAR1HRH3 | |
| SCHEMBL4405620 | 0.72 | KEAP1 (0.33) | KEAP1 | |
| SCHEMBL4444127 | 0.72 | — | — | |
| SCHEMBL4743163 | 0.69 | HTR2A (0.46) | HTR2AHTR2CHTR2BTAAR1HRH3 | |
| SCHEMBL28295966 | 0.68 | HRH3 (0.39) | HTR2AHTR2CHTR2BTAAR1HRH3 | |
| SCHEMBL3395198 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101305010-A | Raf inhibitor compounds and methods of use thereof | ARRAY BIOPHARMA INC (US) | 2008-11-12 | — | — | CN | disclosed |