Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 6/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4743163 | 0.85 | HTR2A (0.46) | HTR2AHTR2CHTR2BTAAR1HRH3 | |
| SCHEMBL5109988 | 0.79 | LTB4R (0.34) | LTB4R | |
| SCHEMBL5104355 | 0.78 | LTB4R (0.36) | LTB4R | |
| SCHEMBL2085294 | 0.78 | LTB4R (0.41) | HTR2CLTB4R | |
| SCHEMBL27277657 | 0.77 | HTR2A (0.41) | HTR2AHTR2CHTR2BHRH1TAAR1 | |
| SCHEMBL2690986 | 0.75 | — | — | |
| SCHEMBL6050537 | 0.75 | KDM4E (0.34) | LTB4R | |
| SCHEMBL5104136 | 0.74 | — | — | |
| SCHEMBL5799093 | 0.73 | ALDH1A1 (0.39) | HRH3 | |
| SCHEMBL27720648 | 0.73 | HTR2A (0.41) | HTR2AHTR2CHTR2BHRH1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023269-A | 3-aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0273658-B1 | 3-ARYLOXY-3-SUBSTITUTED PROPANAMINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| US-4956388-A | ANTIDEPRESSANTS, ANTIANXIETY, TREATMENT OF OBESITY, ADDICTION TO SMOKING AND ALCOHOL | ELI LILLY AND COMPANY (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0273658-A1 | 3-Aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1988-07-06 | — | — | EP | disclosed |