SCHEMBL27722258

SCHEMBL27722258

CC(C)(C)c1nc2c(N)cc(Cl)cn2c1NCC(=O)NO

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 11/20 0.33
TRPA1 O75762 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27722215 0.88 PABPC1 (0.34) HDAC1
SCHEMBL27701824 0.83 HDAC1 (0.34) HDAC1
SCHEMBL27722198 0.82
SCHEMBL27722380 0.80 HDAC1 (0.40) HDAC1
SCHEMBL27722191 0.80 TSPO (0.35) HDAC1
SCHEMBL27701660 0.78 GAA (0.46) HDAC1
SCHEMBL27722211 0.77 PLAU (0.35)
SCHEMBL27722195 0.77 KMT2A (0.32) HDAC1
SCHEMBL27722214 0.74 HDAC1 (0.39) HDAC1
SCHEMBL27722329 0.71 KDM4E (0.38) HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101163703-B Imidazo [1,2-A ] pyridine derivatives as Peptide Deformylase (PDF) inhibitors NOVARTIS AG 2010-12-15 CN disclosed
CN-101163703-A Imidazo [1, 2-A ] pyridine derivatives as Peptide Deformylase (PDF) inhibitors NOVARTIS AG (CH) 2008-04-16 CN disclosed