Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 10/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.36 |
| ▸ | C5 | P01031 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25022905 | 0.83 | KIF11 (0.44) | GSK3BJAK2 | |
| SCHEMBL27722297 | 0.80 | PDE3B (0.33) | MAPK1GSK3BJAK2JAK1TYK2 | |
| SCHEMBL3603415 | 0.75 | KMT2A (0.50) | MAPK1MEN1KMT2AITK | |
| SCHEMBL3604450 | 0.75 | PRKAB2 (0.42) | MAPK1MAPTGSK3BJAK2JAK1 | |
| SCHEMBL176792 | 0.73 | PDPK1 (0.54) | MAPK1GSK3BJAK2JAK1TYK2 | |
| SCHEMBL27381558 | 0.72 | HPGD (0.47) | PTGS2MEN1MAPTPTGS1KMT2A | |
| Hydrochloric Acid SCHEMBL177126 | 0.72 | PDPK1 (0.53) | MAPK1GSK3BJAK2JAK1TYK2 | |
| SCHEMBL10189221 | 0.72 | KIF11 (0.47) | MEN1KMT2AGSK3B | |
| SCHEMBL130781 | 0.72 | ITK (0.47) | MAPK1MAPTITK | |
| SCHEMBL3603266 | 0.71 | MAP2K4 (0.52) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101166733-A | Pyrazole derivatives as phosphodiesterase 4 inhibitors | MEMORY PHARM CORP (US) | 2008-04-23 | — | — | CN | disclosed |