Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 4/20 | 0.31 |
| ▸ | ITK | Q08881 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25022905 | 0.83 | KIF11 (0.44) | PDE3BPDE3AGSK3BJAK2PRMT5 | |
| SCHEMBL27722296 | 0.80 | MAPK1 (0.37) | GSK3BITKMAPK1JAK2JAK1 | |
| SCHEMBL15651827 | 0.76 | TTK (0.49) | PDE3BPDE3AGSK3BJAK2JAK1 | |
| SCHEMBL29957557 | 0.76 | TTK (0.49) | PDE3BPDE3AGSK3BJAK2JAK1 | |
| SCHEMBL130781 | 0.72 | ITK (0.47) | PDE3BPDE3AITKMAPK1 | |
| SCHEMBL10189221 | 0.72 | KIF11 (0.47) | PDE3BPDE3AGSK3BPRMT5WDR77 | |
| SCHEMBL17828603 | 0.71 | HTR1D (0.41) | GSK3BPRMT5WDR77 | |
| SCHEMBL5790250 | 0.70 | PDE3B (0.36) | PDE3BPDE3AGSK3BJAK2JAK1 | |
| SCHEMBL11388 | 0.70 | PDPK1 (0.58) | PDE3BPDE3AGSK3BJAK2PRMT5 | |
| SCHEMBL16095565 | 0.70 | AXL (0.50) | PDE3BPDE3AGSK3BJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101166733-A | Pyrazole derivatives as phosphodiesterase 4 inhibitors | MEMORY PHARM CORP (US) | 2008-04-23 | — | — | CN | disclosed |